A Malaysia Airlines 777 carrying 295 passengers and crew has reportedly crashed in Ukraine.

At this time, Malaysia Airlines is only confirming that they have lost contact with the plane:

More:

There are unconfirmed reports that the 777 was shot down:

This is alleged to be video taken near the crash site:

There are also unconfirmed reports that “pro Russian separatists” downed the Malaysia Airlines jet thinking it was a Ukrainian cargo plane.

The victims reportedly include 23 U.S. citizens:

Editor’s note: This post has been updated with additional tweets.

Update:

The Wall Street Journal is reporting that a surface-to-air missile was fired at the Malaysia Airlines plane:

More via ABC News’ Jonathan Karl: